Ben Affleck is Nick Dunne, husband happy and fulfilled. On the fifth anniversary of his marriage to Amy (Rosamund Pike), his life takes a tragic turn, for Amy disappears without a trace from their home on the Mississippi River. Assaulted press, police and the parents of Amy, Nick seems to display a strange behavior, fueled by lies and inappropriate attitudes. The charges are collected against Nick, and almost every couple in town begins to wonder how well they know their partner for life. Aided only by his half-sister, Margo, Nick tries to prove his innocence. But how can nevertheless be explained disappearance of Amy?