Peter Parker (played by Andrew Garfield) is a retired high schooler who was abandoned by parents in childhood and left in the care of Uncle Ben (played by Martin Sheen) and Aunt May (played by Sally Field). Like many other young people his age, Peter is looking for its own identity. At the same time, living his first love – with Gwen Stacy (played by Emma Stone). Together, they discover the meaning of love and involvement in a relationship that turns out to be full of secrets.
Discovering a mysterious briefcase that belonged to his father, Peter decides to start the footsteps of his parents, to understand the reasons which made him leave. His research lead him directly to Oscorp lab of Dr. Curt Connors and (Rhys Ifans), his colleague and project partner of his father. You must confront the alter-ego of Dr. Connors, an evil character named Lizard. Thus, Peter is forced to take some decisions that will totally change her life. Its special powers will make him a hero, Spider-Man.